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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are typically characterized by a focus on the practical aspects of the research design, like the recruitment process and consent as well as adherence to the use of routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for 프라그마틱 데모 practical trials to be valid and helps reduce the chance of bias in the results. However, too much heterogeneity could cause issues with the trial design.

Pragmatic Play is one of the biggest players on the live casino market, offers a variety of classic table games, including Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta provide customers with an authentic experience in gambling as well as a broad variety of betting options via virtual. The company also has several game shows that make online gambling enjoyable and engaging. Some of these shows are hosted live and others include famous people from the field.

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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. Pragmatic Play is licensed and is regulated by various authorities which include the Malta Gaming Authority and UK Gambling Commission. The games are supported by the latest encryption technology, and the company's security team is on hand to help players resolve any issues they might face.

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Legality

Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. It has earned itself the status of one of the most popular gaming platforms for casinos despite its relative infancy. Its latest releases include Wolves which is a five-reel video slot with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers to help inform their decisions. They can also be a great method to determine the cause-effect relationship between an intervention and its outcomes. They should not, however be used to replace explanatory studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic trial, including recruitment, design and delivery of the intervention, as well as follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to keep in mind that the majority were conducted in primary care settings.