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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically described by their focus on practical aspects of design that include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from various geographical areas. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and also helps reduce the chance of bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.

Pragmatic Play, one of the major players in the live casino market offers a variety of classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta provide customers with an authentic experience in gambling and a wide range of virtual betting options. The company also has created various interactive games to make online gambling enjoyable. Some of these shows feature live hosts, while others are hosted by famous personalities from the industry.

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Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is accessible on mobile devices and in multiple languages. Despite its relatively young age it has already established itself as a leading casino gaming platform. The most recent releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. Usually, they are commissioned by policymakers and 프라그마틱 practitioners in order to guide their decisions. They are also a good way to identify the cause-effect relationship between an intervention and its results. However, they should not, be used to replace explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.

There is a growing trend in the number of pragmatic trials that are published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary-care settings.