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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often described as focusing on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.

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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for a pragmatic trial to be reliable and lessen the chance of bias is also essential. A high degree of heterogeneity, however, can cause problems with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They can also be used to determine the causality of an intervention and its results. They should not, however be used to replace explanatory studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace tests for explanations or if they are a complement to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove a physiological hypothesis or 프라그마틱 무료스핀 clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study that includes the recruitment, design, and delivery of the intervention and 프라그마틱 무료스핀 its follow-up.

There is a growing increase in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary care settings.